Sonia Missiroli began her scientific career in 2008 as a Master’s student at the Signal Transduction Laboratory, University of Ferrara (Italy). In 2016, she obtained her PhD in Biochemistry, Molecular Biology and Biotechnology at the University of Ferrara under the supervision of Prof. Paolo Pinton.
Her doctoral research focused on demonstrating that several oncosuppressors and oncogenes localize at endoplasmic reticulum–mitochondria membranes, where they can alter mitochondria-associated membrane (MAM) functions and modulate different cell death programs. In particular, she investigated the molecular mechanisms through which the promyelocytic leukemia protein (PML) exerts its essential role in cell survival.
During her PhD, she joined Michele Pagano’s laboratory (Department of Pathology, NYU Cancer Institute, New York University School of Medicine, and Howard Hughes Medical Institute, New York, USA), where she studied the molecular events leading to dysregulated ubiquitin ligase activity. She continues to collaborate with Prof. Pagano and with Dr. Shafi Kuchay, Assistant Professor at the University of Illinois at Chicago, integrating basic research with the study of human cancers.
During her postdoctoral training, her research focused on NLRP3 inflammasome activation and its relevance in different pathophysiological conditions. She has been involved as a collaborator in the European Research Council project (853057-InflaPML) and in the AIRC (Associazione Italiana per la Ricerca sul Cancro) project (IG 2017, ID 19803).
In January 2023, she became a Researcher at the University of Ferrara (Italy).
She also investigated the role of the NLRP3 inflammasome in migraine as Principal Investigator of a project funded by the Italian Ministry of Health (Progetto GR-2019-12369646). She is co-inventor of three Italian patents and one international patent on NLRP3 inhibitors.
Actually, she is Associate Professor of General Pathology, Department of Life Science, Health, and Health Professions, Link Campus University.
Curriculum Vitae OFFICE HOURS
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